Cancer Biotechnology

Science, Innovation, Curiosity

Leveraging gene tools to design new therapeutic interventions



We are employing vectors to genetically engineer cancer and immune cells to explore new therapeutic interventions and unravel new biological insights.

our group


We are a group of scientists and students with academic formation in biomedical sciences. Ours is not another job, but a responsibility.  A big one. 

Our lab

About us

Our team is part of the Unit of Prof. Luigi Naldini, director of the San Raffaele Telethon Institute for Gene Therapy, located at the IRCCS San Raffaele, in Italy, Milan.

Selected Publications

14 January 2024

Harnessing lentiviral vectors for in vivo gene therapy of liver metastases

Giovanna Giacca, Luigi Naldini, Mario Leonardo Squadrito

 2024 Jan; 14(1): e1542.

doi: 10.1002/ctm2.1542

26 December 2023

VEGF-C-expressing TAMs rewire the metastatic fate of breast cancer cells

Kaveri Banerjee, Thomas Kerzel, Tove Bekkhus, Sabrina de Souza Ferreira, Tatjana Wallmann, Majken Wallerius, Laura-Sophie Landweh, Dennis Alexander Agardy, Nele Schauer, Anna Malmerfeldt, Jonas Bergh, Margarita Bartish, Johan Hartman, Arne Östman, Mario Leonardo Squadrito*@, Charlotte Rolny*@

Cell Reports 2023 Volume 42, Issue 12, 113507

Available online 19 October 2023

In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases

Kerzel T*, Giacca G*, Beretta S, Bresesti C, Notaro M, Scotti GM, Balestrieri C, Canu T, Redegalli M, Pedica F, Genua M, Ostuni R, Kajaste-Rudnitski A, Oshima M, Tonon G, Merelli I, Aldrighetti L, Dellabona P, Coltella N, Doglioni C, Rancoita PMV, Sanvito F, Naldini L#, Squadrito ML#.

Cancer Cell. 2023 Oct 13:S1535-6108(23)00347-1

Laboratory-Scale Lentiviral Vector Production and Purification for Enhanced Ex Vivo and In Vivo Genetic Engineering.

Soldi M, Sergi Sergi L, Unali G, Kerzel T, Cuccovillo I, Capasso P, Annoni A, Biffi M, Rancoita PMV, Cantore A, Lombardo A, Naldini L, Squadrito ML*, Kajaste-Rudnitski A*.

A.Mol Ther Methods Clin Dev. 2020 Oct 20;19:411-425.

EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens.

Squadrito ML, Cianciaruso C, Hansen SK, De Palma M.
Nat Methods. 2018 Mar;15(3):183-186. 


We acknowledge Fondazione CARIPLO and FRRB for supporting our Research. – Thanks for visiting our website!