A Postdoctoral Research Fellow position is immediately available at San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) in Milan in the Targeted Cancer Gene Therapy Unit headed by Prof. Luigi Naldini and supervised by Dr. Mario Leonardo Squadrito (Project Leader).

The project

The successful candidate will work on a project focused on understanding the role of cancer cell-derived extracellular vesicles (EV) in promoting liver metastases. She/He will employ mouse models of colorectal cancer and experimental liver metastases. The candidate will exploit gene-based technologies to modulate secretion, content and uptake of EVs. The candidate will focus on understanding the effects of cancer cell-derived EVs on tumor immune evasion and liver metastases.


  • We are looking for a highly motivated and talented candidate with a strong background in cancer biology.
  • Master’s Degree in biology, biotechnology or similar, and Ph.D. in the biomedical field, or Medical Doctorate.
  • Previous experience in oncology research and background in immunology are considered an advantage.
  • At least one first author publication in an international peer-reviewed journal.

Required technical skills

  • Mouse handling, cellular and molecular biology techniques including manipulation of primary cells, extraction of DNA, RNA, quantitative PCR.
  • Flow cytometry.
  • Capacity to work in team and meet deadlines, excellent communication and multitasking skills.
  • Oral and written command of the English language.

The successful candidate will be involved in a multi-disciplinary and collaborative research environment with a strong emphasis on the development of novel cell and gene therapy strategies for human disease. The host institution is one of the leading research institutes in Italy, equipped with state-of-the-art facilities and infrastructures (single cell omics, next generation sequencing, cell sorting and imaging, animal facilities, GLP laboratories), direct access to clinically relevant human samples and involved in several first-in-human gene therapy trials.

Salary will be competitive at European level based on the qualifications and experience of the successful candidate.

Applications should be submitted to Dr. Mario Leonardo Squadrito ( and should include a presentation letter, a CV with a list of publications and contact information of at least 2 referees. Evaluation of applications/interviews will begin immediately and continue until the position is filled.

Starting date: To be defined – Thanks for visiting our website!