Cancer Biotechnology
Science, Innovation, Curiosity
Leveraging gene tools to design new therapeutic interventions
projects
Research
We are employing vectors to genetically engineer cancer and immune cells to explore new therapeutic interventions and unravel new biological insights.
our group
Team
We are a group of scientists and students with academic formation in biomedical sciences. Ours is not another job, but a responsibility. A big one.
Our lab
About us
Our team is part of the Unit of Prof. Luigi Naldini, director of the San Raffaele Telethon Institute for Gene Therapy, located at the IRCCS San Raffaele, in Italy, Milan.
Selected Publications
14 January 2024
Harnessing lentiviral vectors for in vivo gene therapy of liver metastases
Giovanna Giacca, Luigi Naldini, Mario Leonardo Squadrito
Clin Transl Med. 2024 Jan; 14(1): e1542.
doi: 10.1002/ctm2.1542
26 December 2023
VEGF-C-expressing TAMs rewire the metastatic fate of breast cancer cells
Kaveri Banerjee, Thomas Kerzel, Tove Bekkhus, Sabrina de Souza Ferreira, Tatjana Wallmann, Majken Wallerius, Laura-Sophie Landweh, Dennis Alexander Agardy, Nele Schauer, Anna Malmerfeldt, Jonas Bergh, Margarita Bartish, Johan Hartman, Arne Östman, Mario Leonardo Squadrito*@, Charlotte Rolny*@
Cell Reports 2023 Volume 42, Issue 12, 113507
https://doi.org/10.1016/j.ccell.2023.09.014
Available online 19 October 2023
In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases
Kerzel T*, Giacca G*, Beretta S, Bresesti C, Notaro M, Scotti GM, Balestrieri C, Canu T, Redegalli M, Pedica F, Genua M, Ostuni R, Kajaste-Rudnitski A, Oshima M, Tonon G, Merelli I, Aldrighetti L, Dellabona P, Coltella N, Doglioni C, Rancoita PMV, Sanvito F, Naldini L#, Squadrito ML#.
Cancer Cell. 2023 Oct 13:S1535-6108(23)00347-1
https://doi.org/10.1016/j.ccell.2023.09.014
Mol Ther Methods Clin Dev. 2020 Oct 20;19:411-425.
EVIR: chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens.
Support
We acknowledge Fondazione CARIPLO and FRRB for supporting our Research.
www.cancerbiotechnology.com – Thanks for visiting our website!